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Zycosan® is indicated for the control of clinical signs associated with osteoarthritis in horses.
Uses
Zycosan® is indicated for the control of clinical signs associated with osteoarthritis in horses.
Additional information
Weight
N/A
STRENGTH/SIZE
250mg/ml
PACKAGING
4 Vials. (Box)
INDICATION
For the control of clinical signs associated with osteoarthritis in horses.
DOSAGE AND ADMINISTRATION:
Administer 3 mg/kg (1.4 mg/lb) by intramuscular injection once weekly for four weeks (for a total of four doses). Zycosan is provided in a single use vial and does not contain a preservative. Discard unused vial contents.
CONTRAINDICATIONS
Horses with hypersensitivity to pentosan polysulfate sodium or any of the inactive ingredients in Zycosan should not receive Zycosan. Do not use Zycosan concurrently with other anticoagulant drugs. Do not use in horses with clotting disorders or within 24 hours of surgical procedures (see Warnings and Precautions).
WARNINGS AND PRECAUTIONS
User Safety Warnings:
Not for use in humans. Keep out of reach of children. Pentosan polysulfate sodium is a weak anticoagulant.
Caution should be used when administering Zycosan if you are taking an anticoagulant. In case of accidental self-injection, seek immediate medical attention. If product comes into contact with skin, rinse skin thoroughly with water and seek medical attention if needed. To obtain a Safety Data Sheet (SDS), contact Dechra at (866) 933-2472.
Animal Safety Warnings and Precautions:
Zycosan has been shown to prolong coagulation parameters up to 24 hours after injection, therefore caution should be used when administering this drug before or after strenuous activities (see Target Animal Safety). Due to the anticoagulant effects, this drug may exacerbate Exercise Induced Pulmonary Hemorrhage (EIPH).
The concurrent use of NSAIDs with Zycosan has not been evaluated. Due to the anticoagulant effects of Zycosan and known anticoagulant effects of some NSAIDs, caution should be used if NSAIDs are concurrently administered. Horses concurrently treated with Zycosan and NSAIDs should be monitored for hemorrhage or other clinical signs of abnormal bleeding (e.g., petechiae, ecchymosis, or epistaxis).
The safety of long-term repeat use of Zycosan has not been evaluated.
Pigmentary changes in the retina (pigmentary maculopathy) have been reported in human patients following long-term oral use of pentosan polysulfate sodium. It is not known if a similar finding occurs in horses.
The safe use of Zycosan has not been evaluated in breeding, pregnant, or lactating horses.
Other Warnings:
Do not use in horses intended for human consumption.
ADVERSE REACTIONS
In a clinical field effectiveness study, two hundred thirty-seven horses (120 Zycosan and 117 saline control) were evaluated for field safety (see Effectiveness). All doses of Zycosan were administered in the neck muscle.
Injection site reactions were the most frequently reported adverse reactions during the study. Injection site reactions were associated with clinicopathology changes in some cases. Other adverse reactions reported in more than one horse were prolongation of coagulation parameters (activated partial thromboplastin time (aPTT) and prothrombin time (PT)), lethargy, behavior changes, and colic.
Storage Instructions
Store at room temperature 68-77°F (20-25°C), with excursions to 59-86°F (15-30°C).
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