Domidine (Detomidine) Injection for Horses

Name: Domidine (Detomidine) Injection for Horses
SKU: 77692
Availability: InStock

Price range: $ 116.99 through $ 417.99 - Plus Tax*

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ONLY FOR VETERINARIAN’S USE.

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Categories: Horse Medications, Horse Sedatives

Description
Additional information

Description

Description

Detomidine Hydrochloride Injection is a non-narcotic sedative and analgesic for use in horses. Each ml contains 10 mg detomidine hydrochloride. Indicated for use as a sedative and analgesic to facilitate minor surgical and diagnostic procedures in mature horses and yearlings. It has been used successfully to calm fractious horses, to provide relief from abdominal pain and to facilitate medical procedures. Detomidine Hydrochloride is given intravenous (IV) or intramuscular (IM), depending upon application, and is typically administered at the rate of 0.2 or 0.4 ml per 220 lbs. body weight, depending on the depth and duration of sedation or anesthesia required.

Uses (for Veterinarian’s use only)

Detomidine Hydrochloride is indicated for use as a sedative and analgesic to facilitate minor surgical and diagnostic procedures in mature horses and yearlings. It has been used successfully for the following: to calm fractious horses, to provide relief from abdominal pain, to facilitate bronchoscopy, bronchoalveolar lavage, nasogastric intubation, nonreproductive rectal palpations, suturing of skin lacerations, and castrations. Additionally, an approved, local infiltration anesthetic is indicated for castration.

Additional information

STRENGTH	10mg/ml
SIZE	5ml, 20ml
Dosage and Administration	For Sedation: Administer Detomidine Hydrochloride IV or IM at the rates of 20 or 40 mcg detomidine hydrochloride per kg of body weight (0.2 or 0.4 mL of Detomidine Hydrochloride per 100 kg or 220 lb), depending on the depth and duration of sedation required. Onset of sedative effects should be reached within 2–4 minutes after IV administration and 3–5 minutes after IM administration. Twenty mcg/kg will provide 30–90 minutes of sedation and 40 mcg/kg will provide approximately 90 minutes to 2 hours of sedation. For Analgesia: Administer Detomidine Hydrochloride IV at the rates of 20 or 40 mcg detomidine hydrochloride per kg of body weight (0.2 or 0.4 mL of Detomidine Hydrochloride per 100 kg or 220 lb), depending on the depth and duration of analgesia required. Twenty mcg/kg will usually begin to take effect in 2–4 minutes and provide 30–45 minutes of analgesia. The 40 mcg/kg dose will also begin to take effect in 2–4 minutes and provide 45–75 minutes of analgesia. For Both Sedation and Analgesia: Administer Detomidine Hydrochloride IV at the rates of 20 or 40 mcg detomidine hydrochloride per kg of body weight (0.2 or 0.4 mL of Detomidine Hydrochloride per 100 kg or 220 lb), depending on the depth and duration of sedation and analgesia required. Before and after injection, the animal should be allowed to rest quietly.
ADVERSE REACTIONS	Occasional reports of anaphylactic-like reactions have been received, including 1 or more of the following: urticaria, skin plaques, dyspnea, edema of the upper airways, trembling, recumbency, and death. The use of epinephrine should be avoided since epinephrine may potentiate the effects of α – agonists. Reports of mild adverse reactions have resolved uneventfully without treatment. Severe adverse reactions should be treated symptomatically. As with all α – agonists, the potential for isolated cases of hypersensitivity exist, including paradoxical response (excitation).
SIDE EFFECTS	Horses treated with Detomidine Hydrochloride exhibit hypertension. Bradycardia routinely occurs 1 minute after injection. The relationship between hypertension and bradycardia is consistent with an adaptive baroreceptor response to the increased pressure and inconsistent with a primary drug-induced bradycardia. Piloerection, sweating, salivation, and slight muscle tremors are frequently seen after administration. Partial transient penis prolapse may be seen. Partial AV and SA blocks may occur with decreased heart and respiratory rates. Urination typically occurs during recovery at about 45–60 minutes posttreatment, depending on dosage. Incoordination or staggering is usually seen only during the first 3–5 minutes after injection, until animals have secured a firm footing. Because of continued lowering of the head during sedation, mucus discharges from the nose and, occasionally, edema of the head and face may be seen. Holding the head in a slightly elevated position generally prevents these effects.
CONTRAINDICATIONS	Detomidine Hydrochloride should not be used in horses with pre-existing AV or SA block, with severe coronary insufficiency, cerebrovascular disease, respiratory disease, or chronic renal failure. Intravenous potentiated sulfonamides should not be used in anesthetized or sedated horses as potentially fatal dysrhythmias may occur. Information on the possible effects of detomidine hydrochloride in breeding horses is limited to uncontrolled clinical reports; therefore, this drug is not recommended for use in breeding animals.
WARNINGS	Do not use in horses intended for human consumption. Not for human use. Keep out of reach of children.
PRECAUTIONS	Before administration, careful consideration should be given to administering Detomidine Hydrochloride to horses approaching or in endotoxic or traumatic shock, to horses with advanced liver or kidney disease, or to horses under stress from extreme heat, cold, fatigue, or high altitude. Protect treated horses from temperature extremes. Some horses, although apparently deeply sedated, may still respond to external stimuli. Routine safety measures should be employed to protect practitioners and handlers. Allowing the horse to stand quietly for 5 minutes before administration and for 10–15 minutes after injection may improve the response to Detomidine Hydrochloride. Detomidine Hydrochloride is a potent α -agonist, and extreme caution should be exercised in its use with other sedative or analgesic drugs for they may produce additive effects. When using any analgesic to help alleviate abdominal pain, a complete physical examination and diagnostic work-up are necessary to determine the etiology of the pain. Food and water should be withheld until the sedative effect of Detomidine Hydrochloride has worn off.