| Possible Side Effects |
The most common doxycycline side effects include nausea and vomiting, upset stomach, loss of appetite, mild diarrhea, skin rash or itching, darkened skin color, and vaginal itching or discharge.
Get emergency medical help if you have any signs of an allergic reaction to doxycycline (symptoms include hives, difficulty breathing, and swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you begin using this medicine.
Other serious doxycycline side effects may occur. Call your doctor at once if you have:
severe stomach pain, diarrhea that is watery or bloody;
throat irritation, trouble swallowing;
chest pain, irregular heart rhythm, feeling short of breath;
little or no urination;
low white blood cell counts – fever, chills, swollen glands, body aches, weakness, pale skin, easy bruising or bleeding;
severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes;
loss of appetite, upper stomach pain (that may spread to your back), tiredness, nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes).
This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may also report side effects to the FDA at 1-800-FDA-1088.
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| Precautions |
Gentamicin is potentially nephrotoxic, therefore renal function should be assessed prior to and regularly during treatment. Adequate therapeutic peak and trough serum concentrations of gentamicin should be maintained and higher potentially toxic levels should be avoided during therapy. Dosage adjustment is required in children and in patients with renal dysfunction (See WARNINGS AND PRECAUTIONS, Renal, Special Populations, Pediatric (≤ 12 years of age) and Geriatrics (≥ 65 years of age); Monitoring and Laboratory Tests, Renal; ADVERSE REACTIONS; DOSAGE AND ADMINISTRATION; CLINICAL PHARMACOLOGY).
Gentamicin is potentially ototoxic (vestibular and auditory), therefore patients receiving Gentamicin Injection USP should be closely monitored for eighth cranial nerve toxicity. The ototoxicity is usually associated with high serum levels and renal insufficiency (See WARNINGS AND PRECAUTIONS, Ear/Nose/Throat; Monitoring and Laboratory Tests, Audiological Assessment; ADVERSE REACTIONS). ï‚· The prior/concurrent and/or sequential system or topical use of other potentially nephrotoxic/neurotoxic drugs should be avoided with Gentamicin Injection USP treatment (See WARNINGS AND PRECAUTIONS, Ear/Nose/Throat, and Renal; DRUG INTERACTIONS, Drug-Drug Interactions).
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